Diagnosis of a female with cloaca should be suspected in a female born with an imperforate anus and small looking genitalia. The diagnosis can be made clinically. Failure to identify a cloaca as being present in a newborn may be dangerous as more than 90% have associated urological problems. The goal for treatment of a female born with cloaca is to achieve bowel control, urinary control, and sexual function, which includes menstruation, intercourse, and possibly pregnancy. Cloacas probably occur in 1 in 20,000 live births.  
Cloacas appear in a wide spectrum of variation in females born with the malformation. The single orifice, called a common channel, may occur varying in length from 1 to 10cm. The length of the common channel can be used to judge prognostic outcomes and technical challenges during surgical repair. A common channel less than 3cm in length usually have a good sphincter muscles and a well developed sacrum.
The prognostic outcomes for this type of cloaca are good for bowel control and urinary function. The surgical repair for this type of cloaca can usually be done by performing posterior sagittal approach without opening of the abdomen. A common channel longer than 3 cm in length usually have poor sphincter muscles and a poor sacrum, suggesting a prognostic outcome for bowel control and urinary function to be less likely. Common channels longer than 3cm are generally considered more complex and more technically challenging in surgical repair.
- Jenkins D, Bitner-Glindzicz M, Thomasson L; et al. (2007). "Mutational analyses of UPIIIA, SHH, EFNB2 and HNF1beta in persistent cloaca and associated kidney malformations". J Pediatr Urol. 3 (1): 2–9. doi:10.1016/j.jpurol.2006.03.002. PMID 17476318.
- Spitz, Lewis; Coran, Arnold G (2006), Operative Pediatric Surgery (6th ed.), London: Hodder Arnold, pp. 503–519.
- Ashcroft, Keith; Holcomb, George; Murphy, J Patrick (2005), Pediaric Surgery (4th ed.), Philadelphia: Elsevier Saunders, pp. 496–517.